One Cycle Fuels Another: The Energetics of Neurotransmitter Release
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چکیده
منابع مشابه
One Cycle Fuels Another: The Energetics of Neurotransmitter Release
In this issue of Neuron, Ashrafi et al. (2017) show that activity induces translocation of the insulin-regulated glucose transporter GLUT4 to the plasma membrane, where it sustains the ATP production required for synaptic vesicle cycling. However, translocation occurs from presynaptic membranes other than synaptic vesicles and involves a distinct molecular mechanism.
متن کاملNeurotransmitter : Release
The nervous system is composed of networks of cells that engage in coordinated circuits to permit neural function. Within these precise neural circuits, communication between individual cells is primarily chemical in nature. Neurotransmitter release via exocytosis of neurotransmitter-filled synaptic vesicles is a fundamental step in this process. Here we overview the biochemical processes that ...
متن کاملCalcium control of neurotransmitter release.
Upon entering a presynaptic terminal, an action potential opens Ca(2+) channels, and transiently increases the local Ca(2+) concentration at the presynaptic active zone. Ca(2+) then triggers neurotransmitter release within a few hundred microseconds by activating synaptotagmins Ca(2+). Synaptotagmins bind Ca(2+) via two C2-domains, and transduce the Ca(2+) signal into a nanomechanical activatio...
متن کاملMolecular analysis of neurotransmitter release.
The synaptic vesicle cycle can now be subdivided into a series of defined steps. These are the tethering of the SSV at the active site of the presynaptic membrane, followed by docking and by an ATP-dependent phase, termed priming. Fusion of the primed SSV with the plasma membrane is triggered by CA2+ entry through specific Ca2+ channels. All the steps in the SSV life cycle are regulated through...
متن کاملPictures of the prologue to neurotransmitter release.
Membrane fusion and fission determine compartmentalization in eukaryotic cells and uptake or secretion of various molecular species. For example, a very rapid, tightly regulated, Ca-triggered fusion event releases neurotransmitters into the synaptic cleft (1). A long history of identifying and characterizing its essential components has allowed in vitro reconstitution, as modeled by fusion of t...
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ژورنال
عنوان ژورنال: Neuron
سال: 2017
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.01.024